I tried it for CRPS. Didn't do much for the pain itself but my sleep improved dramatically, which indirectly helped everything else. Stayed on it for that reason alone. The vivid dreams thing is real though.
My MS neuro is very pro-LDN as an add-on to my regular DMT. There's some interesting research about it modulating the immune system rather than suppressing it. I've been on it 6 months and my fatigue is slightly better.
I've been on LDN for about 8 months for fibro. First two weeks I had vivid dreams — like WILD vivid — and some nausea. After that it settled. By month 3 I noticed my baseline pain dropped from like a 6 to a 4. It's not a miracle but a two-point drop in daily pain is significant. My doctor started me at 1.5mg and slowly titrated up to 4.5mg.
"Burned by cautious hope" is the most chronic illness sentence I've ever read. I haven't tried LDN but following this thread closely.
